MELANOMAS NO CUTÁNEOS DE CABEZA Y CUELLO. ENFERMEDAD DE PRONÓSTICO SOMBRÍO

Abstract

Background: Non cutaneous are 1-7% of all melanoma. The prognosis is poor in spite of which, technological progress may

change the outcome.

Objective: To discover factors which allow to define progress of last 20 years.

Design: Retrospective, observational.

Setting: Public Hospital of tertiary care.

Population: 30/56 male patients with 1.15/1 rate. Mean age 61.07 years old. Priority sites in mucosal melanoma were palate with

22-39.2% and paranasal sinus with 9 (16%). Ocular melanomas were 42.8% of the sample. 94.6% were EI.

Methods: Extention of surgery was simple resection in 13/56 (23.2%), ocular enucleation in 14/56 (25%), orbit exenteration in 5/56 (9%) maxilectomy in 20/56 (35.7%), craniofacial resection in 3 and nasal amputation in 1.

Results: Morbility was 51.7% and mortality 1.7%. 67.8% of the sample recurred. Multivariate analysis for recurrence showed that rinosinusal and conjuntival sites unfavorably influence on that event. At close of observation 42/56 (75%) was dead, 85.8% of them for specific cause. Only 2 death happened after 60 months. Five years specific survival was 31.9%. Palate and stage I were favo- rable sites with statistic significance.

Conclusions: Other paradigms of treatment are urgently necessary for this disease which outcome was not substantially modified

in the last 20 years.