FACTORES PREDICTORES DE METÁSTASIS GANGLIONAR EN EL CARCINOMA DIFERENCIADO DE TIROIDES

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Jorge E. Falco
Álvaro Otero Muñoz
Manuel R. Montesinos

Abstract

Background: reliable prognostic factors of lymph node metastasis are needed to adapt initial surgical treatment of patients with differentiated thyroid carcinoma.


Objetive: to determine the frequency and predictive factors associated with lymph node metastasis in patients oper- ated on for differentiated thyroid carcinoma.


Setting: private practice.


Design: retrospective observational.


Population: between January 2000 and August 2010, 600 patients with 639 tumours (39 bilateral) underwent total thyroidectomy and therapeutic neck dissection only when there was biopsy proved lymph node metastasis.


Method: review of clinical records and pathological reports.


Results: 145 patients (22.7 %) had histologically positive lymph nodes. Multivariate analysis showed that less than 45 years (p = 0.001), palpable adenopathy (p = 0.0001), multicentricity (p = 0.005) and extracapsular invasion (p = 0.0001) were independent risk factors of lymph node metastasis. These factors, together, had high specificity (97 %) but low sensibility (40 %). Metastasis in jugular lymph nodes with normal central nodes (skip metastasis) was found in 29 (5.54 %) cases.


Conclusions: even though some of the factors studied proved to be of prognostic value, additional variables are needed to better define surgical management.

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How to Cite
Falco, J. E., Otero Muñoz , Álvaro, & Montesinos, M. R. (2022). FACTORES PREDICTORES DE METÁSTASIS GANGLIONAR EN EL CARCINOMA DIFERENCIADO DE TIROIDES. Revista Argentina De Cirugía, 102(2), 57–61. Retrieved from https://revista.aac.org.ar/index.php/RevArgentCirug/article/view/476
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